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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：8975
Application：Blocking Peptide of K111883P Antibody
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| Name | USP13 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q92995 |
| Gene ID | 8975 |
| Interval Range | 145-195/863aa |
| Background | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1， MITF， SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1， a key regulator of autophagy， leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10， an essential regulator of p53/TP53 stability. In turn， PIK3C3/VPS34-containing complexes regulate USP13 stability， suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2， thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves ’Lys-63’-linked polyubiquitin chains. In contrast to USP5， it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however， additional experiments are required to confirm such data. |
| Application | Blocking Peptide of K111883P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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