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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：10721
Application：Blocking Peptide of K112920P Antibody
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| Name | POLQ Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | O75417 |
| Gene ID | 10721 |
| Interval Range | 2430-2480/2590aa |
| Background | DNA polymerase that promotes microhomology-mediated end-joining (MMEJ)， an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963， PubMed:25643323).MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements， such as telomere fusions， some of them leading to cellular transformation (PubMed:25642963， PubMed:25643323).POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963).POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway， thereby preventing genomic havoc by resolving unrepaired lesions (By similarity).The polymerase acts by binding directly the 2 ends of resected double-strand breaks， allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region using the opposing overhang as a template. Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323).The polymerase activity is highly promiscuous: unlike most polymerases， promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084， PubMed:21050863， PubMed:22135286).Also exhibits low-fidelity DNA synthesis， translesion synthesis and lyase activity， and it is implicated in interstrand-cross-link repair， base excision repair and DNA end-joining (PubMed:14576298， PubMed:18503084， PubMed:19188258， PubMed:24648516).Involved in somatic hypermutation of immunoglobulin genes， a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). |
| Application | Blocking Peptide of K112920P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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