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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：11176
Application：Blocking Peptide of K112925P Antibody
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| Name | BAZ2A Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q9UIF9 |
| Gene ID | 11176 |
| Interval Range | 80-130/1905aa |
| Background | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes， which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication， transcription， and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex. The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex. Within the NoRC-5 ISWI chromatin remodeling complex， mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases， leading to heterochromatin formation and transcriptional silencing (By similarity. In the complex， it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1， leading to repress RNA polymerase I transcription (By similarity. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on ’Lys-16’ (H4K16ac， leading to deacetylation of H4K5ac， H4K8ac， H4K12ac but not H4K16ac (By similarity. Specifically binds pRNAs， 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity. |
| Application | Blocking Peptide of K112925P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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