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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：790
Application：Blocking Peptide of K114145P Antibody
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| Name | CAD Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | P27708 |
| Gene ID | 790 |
| Interval Range | 1-51/1972aa |
| Background | Double-strand break (DSB repair protein involved in response to DNA damage， telomere dynamics and class-switch recombination (CSR during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR repair protein BRCA1. In response to DSBs， phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR， leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at ’Lys-15’ (H2AK15Ub and histone H4 dimethylated at ’Lys-20’ (H4K20me2， two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR during antibody genesis， a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity. In contrast， it is not required for classic NHEJ and V(DJ recombination (By similarity. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1. |
| Application | Blocking Peptide of K114145P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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