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My CartCAS：158563-45-2
Molecular Formula：C61H87N15O9S1
Molecular Weight：1206.5
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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| Product Type | Peptides |
| CAS | 158563-45-2 |
| Sequence(1LC) | MPFRWFKPV-NH2 |
| Sequence(3LC) | Met-Pro-Phe-Arg-Trp-Phe-Lys-Pro-Val-NH2 |
| Molecular Formula | C61H87N15O9S1 |
| Molecular Weight | 1206.5 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Hormone and Related Peptides |
| Background | Nonapeptide-1 (Melanostatine-5)， a peptide hormone， is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM， respectively). Nonapeptide-1 inhibits melanin synthesis， and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland， skin cancer. |
| Reference | [1]. Jayawickreme CK， et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269(47):29846-54. [2]. Schi?th， H.B.， et al. Characterization of the binding of MSH-B， HB-228， GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31(6)， 565-571 (1997). [3]. Jiaoquan Chen， et al. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Postepy Dermatol Alergol. 2022 Apr;39(2):327-335. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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