LH-RH (4-10)
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Cat.No：CLP1834 Solarbio
CAS：51776-33-1
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
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MAPK
NF-κB
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| Product Type | Peptides |
| CAS | 51776-33-1 |
| Sequence(1LC) | SYGLRPG-NH2 |
| Sequence(3LC) | Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
| Molecular Formula | C33H53N11O9 |
| Molecular Weight | 747.84 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Neuropeptides & Related Peptides |
| Background | LH-RH (4-10) is a heptapeptide， one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes. |
| In Vitro | The formation of LHRH 4-10， LHRH 7-10， and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor)， Thiorphan (HY-W013375) (an EP24.11 inhibitor)， and Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor). LH-RH (4-10) inhibits the binding of 125I-labeled GnRH to monoclonal antibody P81662 with an IC50 value of 23 pM. |
| Reference | [1]. Yang X， et al. Enzymatic degradation of luteinizing hormone releasing hormone (LHRH)/[D-Ala6]-LHRH in lung pneumocytes. Pharm Res. 1998 Sep;15(9):1480-4. [2]. Talwar GP， et al. Bioeffective monoclonal antibody against the decapeptide gonadotropin-releasing hormone: reacting determinant and action on ovulation and estrus suppression. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1228-31. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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