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My Cart> Cell Biology > Cell Detection > Cell Growth Factor > Recombinant Human EGFR/HER1/ERBB1Purity：≥95% as determined by reducing SDS-PAGE.
Storage：Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Appearance：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Qty：
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| Appearance | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Purity | ≥95% as determined by reducing SDS-PAGE. |
| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| Transport Condition | The product is shipped at ambient temperature. |
| Background | The EGFR subfamily of receptor tyrosine kinases is composed of EGFR，ErbB2，ErbB3 and ErbB4.The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily.All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain.The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain.Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2，resulting in cell signaling，heterodimerization tyrosine phosphorylation and kinase activation.It can bind EGF，amphiregulin，TGF-alpha，betacellulin，epiregulin，HB-EGF，epigen，and so on.Its signaling regulates multiple biological functions including cell proliferation，differentiation，motility，and apoptosis.EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4.EGFR is overexpressed in different tumors.Several anti-cancer drugs use EGFR as target. |
| Source | Human cells |
| Solvent | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Endotoxin | Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test. |
| Unit | Piece |
| Specification | 10ug 50ug 500ug 1mg |
Recombinant Human Epidermal Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Leu25-Ser645 is expressed with a 6His tag at the C-terminus.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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