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My CartCAS：171335-80-1
Molecular Formula：C24H22FN3O4
Molecular Weight：435.45
Storage：Powder:-20℃，2 years;Insolvent(mother liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Gray to brown Solid
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| CAS | 171335-80-1 |
| Name | Exatecan |
| Molecular Formula | C24H22FN3O4 |
| Molecular Weight | 435.45 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Gray to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(mother liquid):-20℃，6 months;-80℃，1 year |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | Exatecan is a DNA topoisomerase I (topoisomerase I) inhibitor used in cancer research. |
| Biological Activity | Exatecan (DX-8951) is a DNA topoisomerase I inhibitor， with an IC50 of 2.2 μM (0.975 μg/mL)， and can be used in cancer research.[1-3] |
| Data Literature Source | [1]. Mitsui I， et al. A new water-soluble camptothecin derivative， DX-8951f， exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. [2]. Sun FX， et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63(1):80-5. [3]. Joto N， et al. DX-8951f， a water-soluble camptothecin analog， exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72(4):680-6. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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