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My CartCAS：1191237-69-0
Molecular Formula：C12H13N5O4
Molecular Weight：291.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1191237-69-0 |
| Name | GS-441524 |
| Molecular Formula | C12H13N5O4 |
| Molecular Weight | 291.26 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Target Point | FIPV |
| Passage | Anti-infection |
| Background | GS-441524， a molecular precursor of the pharmacologically active nucleoside triphosphate molecule， is a potent inhibitor of feline infectious peritonitis virus (FIPV). |
| Biological Activity | GS-441524， predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 ， shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV)， with an EC50 of 0.78 μM.[1-3] |
| IC50 | EC50: 0.78 μM (FIPV)[1]. |
| Data Literature Source | [1]. Murphy BG， et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233. [2]. Katherine Yang， et al. What Do We Know About Remdesivir Drug Interactions? Clin Transl Sci. 2020 May 13;10.1111/cts.12815. [3]. Victoria C. Yan， et al. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. ACS Med. Chem. Lett. 2020. |
| Unit | Bottle |
| Specification | 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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