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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Sunitinib Malate(10mM in DMSO,Sterile）CAS：341031-54-7
Molecular Formula：C22H27FN4O2·C4H6O5
Molecular Weight：532.56
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 341031-54-7 |
| Name | Sunitinib Malate(10mM in DMSO,Sterile） |
| Molecular Formula | C22H27FN4O2·C4H6O5 |
| Molecular Weight | 532.56 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | PDGFR;VEGFR2/KDR/Flk-1 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Sunitinib Malate is a potent tyrosine kinase inhibitor that inhibits VEGFR2 and PDGFRβ. |
| Biological Activity | Sunitinib Malate (SU 11248 Malate) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ， respectively. Sunitinib Malate， an ATP-competitive inhibitor， effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.[1-4] |
| Data Literature Source | [1]. Sun L， et al. Discovery of 5-[5-fluoro-2-oxo-1，2- dihydroindol-(3Z)-ylidenemethyl]-2，4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide， a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor r [2]. Ali MM， et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 2011 Mar 2;30(5):894-905. [3]. OFarrell AM， et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. [4]. Mendel DB， et al. In vivo antitumor activity of SU11248， a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Can |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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