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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PHA-793887(10mM in DMSO,Sterile）CAS：718630-59-2
Molecular Formula：C19H31N5O2
Molecular Weight：361.48
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 718630-59-2 |
| Name | PHA-793887(10mM in DMSO,Sterile） |
| Molecular Formula | C19H31N5O2 |
| Molecular Weight | 361.48 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | PHA-793887 is a potent， ATP-competitive CDK inhibitor. |
| Biological Activity | PHA-793887 is a potent， ATP-competitive CDK inhibitor， can inhibit Cdk2， Cdk1， Cdk4， and Cdk9 with IC50s of 8 nM， 60 nM， 62 nM and 138 nM， respectively， and also inhibits glycogen synthase kinase 3β with an IC50 of 79 nM.[1-4] |
| Data Literature Source | [1]. Locatelli G， et al. Transcriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study. Mol Cancer Ther. 2010 May;9(5):1265-73. [2]. Massard C， et al. A first in man， phase I dose-escalation study of PHA-793887， an inhibitor of multiple cyclin-dependent kinases (CDK2， 1 and 4) reveals unexpected hepatotoxicity in patients with solid tumors. Cell Cycle. 2011 Mar 15;10(6):963-70. Epub 2011 Mar 15. [3]. Alzani R， et al. Therapeutic efficacy of the pan-cdk inhibitor PHA-793887 in vitro and in vivo in engraftment and high-burden leukemia models. Exp Hematol. 2010 Apr;38(4):259-269.e2. [4]. Brasca MG， et al. Optimization of 6，6-dimethyl pyrrolo[3，4-c]pyrazoles: Identification of PHA-793887， a potent CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem. 2010 Mar 1;18(5):1844-53. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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