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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > K858(10mM in DMSO,Sterile）CAS：72926-24-0
Molecular Formula：C13H15N3O2S
Molecular Weight：277.34
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 72926-24-0 |
| Name | K858(10mM in DMSO,Sterile） |
| Molecular Formula | C13H15N3O2S |
| Molecular Weight | 277.34 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Eg5(Kinesin) |
| Passage | Cytoskeleton |
| Background | K858 is an ATP-noncompetitive inhibitor of kinesin Eg5. |
| Biological Activity | K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.[1-2] |
| Data Literature Source | [1]. Nakai R， et al. K858， a novel inhibitor of mitotic kinesin Eg5 and antitumor agent， induces cell death in cancer cells. Cancer Res. 2009 May 1;69(9):3901-9. [2]. De Iuliis F， et al. The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. Invest New Drugs. 2016 Aug;34(4):399-406. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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