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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Betulinic acid(10mM in DMSO,Sterile）CAS：472-15-1
Molecular Formula：C30H48O3
Molecular Weight：456.7
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 472-15-1 |
| Name | Betulinic acid(10mM in DMSO,Sterile） |
| Molecular Formula | C30H48O3 |
| Molecular Weight | 456.7 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | Betulinic acid is an inhibitor of eukaryotic topoisomerase I (topoisomerase I). |
| Biological Activity | Betulinic acid is a natural pentacyclic triterpenoid， acts as a eukaryotic topoisomerase I inhibitor， with an IC50 of 5 μM， and possesses anti-HIV， anti-malarial， anti-inflammatory and anti-tumor properties.[1-5] |
| Data Literature Source | [1]. Chowdhury AR， et al. Betulinic acid， a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step， the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8(7):BR254-65. [2]. Gao Y， et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018 Jan-Feb;42(1):49-54. [3]. Kalra J， et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec 26. [4]. Hashimoto F， et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem. 1997 Dec;5(12):2133-43. [5]. Kasperczyk H， et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005 Oct 20;24(46):6945-56. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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