{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Irinotecan(10mM in DMSO,Sterile）CAS：97682-44-5
Molecular Formula：C33H38N4O6
Molecular Weight：586.68
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
Qty：
Size：
| CAS | 97682-44-5 |
| Name | Irinotecan(10mM in DMSO,Sterile） |
| Molecular Formula | C33H38N4O6 |
| Molecular Weight | 586.68 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | Irinotecan is a topoisomerase I inhibitor that prevents religation of DNA strands by binding to the topoisomerase I-DNA complex. |
| Biological Activity | Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor， preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.[1-5] |
| Data Literature Source | [1]. Morales C， et al. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb;56(3):219-26. [2]. Pavillard V， et al. Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. Cancer Chemother Pharmacol. 2002 Apr;49(4):329-35. Epub 2002 Jan 30. [3]. Allegrini G， et al. Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice. Cancer Chemother Pharmacol. 2004 Mar;53(3):261-6. Epub 2003 Dec 5. [4]. Dela Cruz FS， et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016 Oct 31;8(1):116. [5]. Huang MY， et al. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis. Apoptosis. 2016 Feb;21(2):130-42. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no experimental images.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
