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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > beta-Lapachone(10mM in DMSO,Sterile）CAS：4707-32-8
Molecular Formula：C15H14O3
Molecular Weight：242.27
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 4707-32-8 |
| Name | beta-Lapachone(10mM in DMSO,Sterile） |
| Molecular Formula | C15H14O3 |
| Molecular Weight | 242.27 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | β-Lapachone is a naphthoquinone compound that is a topoisomerase I (topoisomerase I) inhibitor. |
| Biological Activity | β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone， acts as a topoisomerase I inhibitor， and induces apoptosis by inhibiting cell cycle progression.[1-3] |
| Data Literature Source | [1]. Li CJ， et al. beta-Lapachone， a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268(30):22463-8. [2]. Vanni A， et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401(1-2):55-63. [3]. Kim TW， et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68(1):27-31. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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