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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Panobinostat(10mM in DMSO,Sterile）CAS：404950-80-7
Molecular Formula：C21H23N3O2
Molecular Weight：349.43
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 404950-80-7 |
| Name | Panobinostat(10mM in DMSO,Sterile） |
| Molecular Formula | C21H23N3O2 |
| Molecular Weight | 349.43 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | HDAC (Histone deacetylases) |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Panobinostat is a non-selective histone deacetylase (HDAC) inhibitor. |
| Biological Activity | Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor， and has antineoplastic activities. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM， stimulates HIV-1 expression in latently infected cells. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma.[1-5] |
| Data Literature Source | [1]. Scuto A， et al. The novel histone deacetylase inhibitor， LBH589， induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100. [2]. Crisanti MC， et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31. [3]. Ocio EM， et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010 May;95(5):794-803. [4]. Banerjee NS， et al. Vorinostat， a?pan-HDAC?inhibitor，?abrogates?productive?HPV-18?DNA?amplification. Proc Natl Acad Sci U S A.?2018 Nov 20;115(47):E11138-E11147. [5]. Barton K， et al. Broad activation of latent HIV-1 in vivo. Nat Commun. 2016;7:12731. Published 2016 Sep 8. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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