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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > 5-Azacytidine(10mM in DMSO,Sterile）CAS：320-67-2
Molecular Formula：C8H12N4O5
Molecular Weight：244.2
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 320-67-2 |
| Name | 5-Azacytidine(10mM in DMSO,Sterile） |
| Molecular Formula | C8H12N4O5 |
| Molecular Weight | 244.2 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | DNA Methyltransferase;Autophagy |
| Passage | Epigenetics;Autophagy |
| Background | 5-Azacytidine is acytidine nucleoside analogue and a DNA methylation inhibitor that specifically inhibits DNA methylation by binding to DNA covalently trapping DNA methyltransferases. 5-Azacytidine regulates gene expression by reducing DNA methylation levels. |
| Biological Activity | 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.[1-4] |
| Data Literature Source | [1]. Christman JK. 5-Azacytidine and 5-aza-2-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95. [2]. Creusot F， et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2-deoxycytidine. J Biol Chem. 1982 Feb 25;257(4):2041-8. [3]. Li LH，et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30(11):2760-9. [4]. Marycz K， et al. 5-Azacytidine?and?Resveratrol?Enhance?Chondrogenic?Differentiation?of?Metabolic?Syndrome-Derived?Mesenchymal?Stem?Cells?by?Modulating?Autophagy.Oxid Med Cell Longev.?2019 May 12;2019:1523140. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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