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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > Curcumin(10mM in DMSO,Sterile）CAS：458-37-7
Molecular Formula：C21H20O6
Molecular Weight：368.38
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 458-37-7 |
| Name | Curcumin(10mM in DMSO,Sterile） |
| Molecular Formula | C21H20O6 |
| Molecular Weight | 368.38 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | P300/CREB;HAT;Keap1-Nrf2 |
| Passage | Epigenetics;NF-κB |
| Background | Curcumin is a specific inhibitor of acetyltransferase p300/CREB binding protein that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin can inhibit NF-κb and MAPKs， and has anti-inflammatory， antioxidant， anti-angiogenesis and other physiological activities. |
| Biological Activity | Curcumin (Diferuloylmethane)， a natural phenolic compound， is a p300/CREB-binding protein-specific inhibitor of acetyltransferase， represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs， and has diverse pharmacologic effects including anti-inflammatory， antioxidant， antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.[1-8] |
| Data Literature Source | [1]. Gao S， et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway， promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915(13)004 [2]. Nasiri M， et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14(6):3449-53. [3]. Cao A， et all. Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. Apoptosis. 2013 Jul 24. [Epub ahead of print] [4]. Jiang H， et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846(13)00150-4. [5]. Guo H， et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha， c-Jun and androgen receptor. Pharmazie. 2013 Jun;68(6):431-4. [6]. Zhu X， et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9(3):e91303. [7]. Balasubramanyam K， et al. Curcumin， a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase， represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J Biol Chem. 2004 Dec 3;279(49):51163-71. [8]. Jun Wan Shin， et al. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Biochem Pharmacol. 2020 Mar;173:113820. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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