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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Acetazolamide(10mM in DMSO,Sterile）CAS：59-66-5
Molecular Formula：C4H6N4O3S2
Molecular Weight：222.25
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 59-66-5 |
| Name | Acetazolamide(10mM in DMSO,Sterile） |
| Molecular Formula | C4H6N4O3S2 |
| Molecular Weight | 222.25 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Carbonic Anhydrase |
| Passage | Metabolic Enzyme&Protease |
| Background | It's a carbonic anhydrase inhibitor. |
| Biological Activity | Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic， antihypertensive and anti-gonococcal activities.[1-6] |
| Data Literature Source | [1]. Hou Z， et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10. [2]. Bayat Mokhtari R， et al. Acetazolamide potentiates the anti-tumor potential of HDACi， MS-275， in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156. [3]. Gao H， et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15(6):9299-9306. [4]. Kassamali R， et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. [5]. Jabeen E， et al. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B. 2013 Aug 5;125:155-63. [6]. Abutaleb NS， et al. In vivo efficacy of acetazolamide in a mouse model of Neisseria gonorrhoeae infection. Microb Pathog. 2022 Mar;164:105454. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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