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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > Astragaloside Ⅳ(10mM in DMSO,Sterile）CAS：84687-43-4
Molecular Formula：C41H68O14
Molecular Weight：784.98
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 84687-43-4 |
| Name | Astragaloside Ⅳ(10mM in DMSO,Sterile） |
| Molecular Formula | C41H68O14 |
| Molecular Weight | 784.98 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Others |
| Passage | Others |
| Background | It is a biologically active saponin that can be used for research in cardiovascular， immune， digestive and nervous systems. Can inhibit the activation of ERK1/2 and JNK. |
| Biological Activity | Astragaloside IV， an active component isolated from Astragalus membranaceus， suppresses the activation of ERK1/2 and JNK， and downregulates matrix metalloproteases (MMP)-2， (MMP)-9 in MDA-MB-231 breast cancer cells.[1-4] |
| Data Literature Source | [1]. Li M， et al. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2016 Dec 20. pii: S0304-3940(16)30994- [2]. He CS， et al. Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3. Cell Physiol Biochem. 2016;40(5):1221-1229. Epub 2016 Dec 14. [3]. Liu L， et al. [Protective effect of astragaloside IV against acute liver failure in experimental mice]. Zhonghua Gan Zang Bing Za Zhi. 2016 Oct 20;24(10):772-777 [4]. Jiang K， et al. Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling. Int Immunopharmacol. 2016 Dec 5;42:195-20 |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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