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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > Dihydromyricetin(10mM in DMSO,Sterile）CAS：27200-12-0
Molecular Formula：C15H12O8
Molecular Weight：320.25
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 27200-12-0 |
| Name | Dihydromyricetin(10mM in DMSO,Sterile） |
| Molecular Formula | C15H12O8 |
| Molecular Weight | 320.25 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | It is a potent dihydropyrimidase inhibitor. Dihydromyricetin activates autophagy by inhibiting mTOR signaling. Dihydromyricetin inhibits mTOR complex (mTORC1/2) formation. |
| Biological Activity | Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.[1-4] |
| Data Literature Source | [1]. Huang CY. Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases. PLoS One. 2015 May 19;10(5):e0127634. [2]. Chang H， et al. Ampelopsin suppresses breast carcinogenesis by inhibiting the mTOR signalling pathway. Carcinogenesis. 2014 Aug;35(8):1847-54. [3]. Kou X， et al. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTORsignal pathway. Oncotarget. 2016 Nov 15;7(46):74484-74495. [4]. Václav Zima， et al. Unraveling the Anti-Influenza Effect of Flavonoids: Experimental Validation of Luteolin and its Congeners as Potent Influenza Endonuclease Inhibitors. Eur J Med Chem. 22 August 2020， 112754. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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