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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > Oridonin(10mM in DMSO,Sterile）CAS：28957-04-2
Molecular Formula：C20H28O6
Molecular Weight：364.43
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 28957-04-2 |
| Name | Oridonin(10mM in DMSO,Sterile） |
| Molecular Formula | C20H28O6 |
| Molecular Weight | 364.43 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Akt |
| Passage | PI3K/Akt/mTOR |
| Background | It is an AKT inhibitor with anti-tumor， antibacterial， anti-inflammatory and other physiological activities， which can be used for related research. |
| Biological Activity | Oridonin (NSC-250682)， a diterpenoid isolated from Rabdosia rubescens， acts as an inhibitor of AKT， with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor， anti-bacterial and anti-inflammatory effects.[1-2] |
| Data Literature Source | [1]. Song M， et al. Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo. Mol Cancer Ther. 2018 Apr 25. pii: molcanther.0823.2017. [2]. Sun B， et al. Oridonin inhibits aberrant AKT activation in breast cancer. Oncotarget. 2018 Feb 1;9(35):23878-23889. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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