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My CartReactivity：Rat,Mouse,Human,Human;Mouse;Rat
Application：IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：8877
Host：Rabbit
Qty：
Size：
| Name | Anti-SPHK1 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | IHC 1:50-200. |
| Target | SPHK1 |
| Background | The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P)，a lipid mediator with both intra- and extracellular functions. Intracellularly，S1P regulates proliferation and survival，and extracellularly，it is a ligand for cell surface G protein-coupled receptors. This protein，and its product S1P，play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory，antiapoptotic，and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Swiss Prot | Q9NYA1 |
| Gene ID | 8877 |
| Subcellular Location | Cytoplasm Nucleus Cell membrane |
| Immunogen | Recombinant protein of human SPHK1 |
| Public Immunogen Range | 100-379aa |
| Calculated MW | 43/44/51kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | bottle |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human;Mouse;Rat Rat Mouse Human |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with SPHK1 antibody diluted at 1:100.
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