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My CartCAS：552325-16-3
Molecular Formula：C24H23N5O
Molecular Weight：397.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 552325-16-3 |
| Name | A-443654 |
| Molecular Formula | C24H23N5O |
| Molecular Weight | 397.47 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Target Point | Akt |
| Passage | PI3K/Akt/mTOR |
| Background | A-443654 is A potent pan-Akt inhibitor that inhibits Akt1， Akt2， and Akt3 with equal potency. |
| Biological Activity | A-443654 is a pan-Akt inhibitor and has equal potency against Akt1， Akt2， or Akt3 within cells (Ki=160 pM).[1-4] |
| Data Literature Source | [1]. Luo Y， et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther. 2005 Jun;4(6):977-86. [2]. Zheng J， et al. Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells. Cancer Lett. 2010 Oct 1;296(1):74-87. [3]. Gallia GL， et al. Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Mol Cancer Ther. 2009 Feb;8(2):386-93. [4]. Zhao Y， et al. Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice. J Steroid Biochem Mol Biol. 2017 Nov;174:96-113. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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