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My CartCAS：451493-31-5
Molecular Formula：C41H44ClFN6O7S2
Molecular Weight：851.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to green yellow Solid
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| CAS | 451493-31-5 |
| Name | AV-412 |
| Molecular Formula | C41H44ClFN6O7S2 |
| Molecular Weight | 851.41 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to green yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | AV-412 is an EGFR inhibitor. |
| Biological Activity | AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75， 0.5， 0.79， 2.3， 19 nM for EGFR， EGFRL858R， EGFRT790M， EGFRL858R/T790M and ErbB2， respectively.[1] |
| Data Literature Source | [1]. Suzuki T， et al. Pharmacological characterization of MP-412 (AV-412)， a dual epidermal growth factor receptorand ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98(12):1977-84. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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