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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Infigratinib phosphateCAS：1310746-10-1
Molecular Formula：C26H34Cl2N7O7P
Molecular Weight：658.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to gray Solid
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| CAS | 1310746-10-1 |
| Name | Infigratinib phosphate |
| Molecular Formula | C26H34Cl2N7O7P |
| Molecular Weight | 658.47 |
| Solubility | Soluble in DMSO ≥1mg/mL |
| Purity | ≥98% |
| Appearance | Off-white to gray Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Target Point | FGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Infigratinib phosphate is an FGFR inhibitor. |
| Biological Activity | Infigratinib phosphate (BGJ-398 phosphate; NVP-BGJ398 phosphate) is a potent inhibitor of the FGFR family with IC50 of 0.9 nM， 1.4 nM， 1 nM， and 60 nM for FGFR1， FGFR2， FGFR3， and FGFR4， respectively.[1-2] |
| Data Literature Source | [1]. Guagnano V， et al. Discovery of 3-(2，6-Dichloro-3，5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398)， A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T [2]. Konecny GE， et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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