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My CartCAS：1190836-34-0
Molecular Formula：C27H23FN4O4S
Molecular Weight：518.56
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 1190836-34-0 |
| Name | Pamufetinib |
| Molecular Formula | C27H23FN4O4S |
| Molecular Weight | 518.56 |
| Solubility | Soluble in DMSO ≥2mg/mL |
| Purity | ≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Target Point | VEGFR;c-Met |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Pamufetinib is a potent inhibitor of VEGFR and c-Met/HGFR. |
| Biological Activity | Pamufetinib (TAS-115) is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET， respectively.[1-2] |
| Data Literature Source | [1]. Fujita H， et al. The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile. Mol Cancer Ther. 2013 Dec;12(12):2685-96. [2]. Nakade J， et al. Triple inhibition of EGFR， Met， and VEGF suppresses regrowth of HGF-triggered， erlotinib-resistant lung cancer harboring an EGFR mutation. J Thorac Oncol. 2014 Jun;9(6):775-83. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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