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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > RGB-286638 free baseCAS：784210-88-4
Molecular Formula：C29H35N7O4
Molecular Weight：545.63
Storage：Powder:2-8℃，2 years.
Purity：≥98%
Appearance：Light yellow to green yellow Solid
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| CAS | 784210-88-4 |
| Name | RGB-286638 free base |
| Molecular Formula | C29H35N7O4 |
| Molecular Weight | 545.63 |
| Solubility | Soluble in DMSO ≥0.3mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to green yellow Solid |
| Storage | Powder:2-8℃，2 years. |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | It is a potent CDK inhibitor， inhibiting the activity of cyclin T1-CDK9， cyclin B1-CDK1， cyclin E-CDK2， cyclin D1-CDK4， cyclin E-CDK3 and p35-CDK5; It also inhibits GSK-3β， TAK1， Jak2 and MEK1. |
| Biological Activity | RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9， cyclin B1-CDK1， cyclin E-CDK2， cyclin D1-CDK4， cyclin E-CDK3， and p35-CDK5 with IC50s of 1， 2， 3， 4， 5 and 5 nM， respectively; also inhibits GSK-3β， TAK1， Jak2 and MEK1， with IC50s of 3， 5， 50， and 54 nM.[1] |
| Data Literature Source | [1]. Cirstea D， et al. Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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