Atrasentan
Cat.No:IAA12870 Solarbio
CAS:173937-91-2
Purity:≥98%
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Purity:≥98%
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Size:
CAS | 173937-91-2 |
Name | Atrasentan |
Purity | ≥98% |
Target Point | Endothelin Receptor |
Passage | GPCR & G Protein |
Background | Atrasentan is an effective endothelin receptor antagonist that inhibits the activity of ETA. |
Biological Activity | Atrasentan (ABT-627) is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA.[1-3] |
IC50 | IC50: 0.055 nM (ETA)[1-3] |
Data Literature Source | [1]. Yuyama H, et al. Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. Eur J Pharmacol. 2004 Sep 13;498(1-3):171-7. [2]. Banerjee S, et al. In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer. Cancer Res. 2007 Apr 15;67(8):3818-26. [3]. Weiss J, et al. Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro. Cancer Chemother Pharmacol. 2011 Oct;68(4):1093-8. |
Unit | Bottle |
Specification | 1mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
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