Darbufelone
Cat.No:ID8440 Solarbio
CAS:139226-28-1
Purity:≥98%
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Purity:≥98%
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Size:
CAS | 139226-28-1 |
Name | Darbufelone |
Purity | ≥98% |
Biological Activity | Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50= 0.19 μM) but is much less potent with PGHS-1 (IC50=20 μM).[1-2] |
IC50 | IC50: 0.19 μM (PGHS-2), 20 μM (PGHS-1)[1] |
Data Literature Source | [1]. Johnson AR, et al. Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 2001 Jun 26;40(25):7736-45. [2]. Ye X, et al. Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo. Cancer Chemother Pharmacol. 2010 Jul;66(2):277-85. |
Unit | Bottle |
Specification | 1mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
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