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My CartReactivity：Human,Mouse,Rat
Application：IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：1139
Purity：CHRNA7
Qty：
Size：
| Name | Anti-CHRNA7 Polyclonal Antibody |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | IHC 1:50-200. |
| Target | Rabbit |
| Background | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains， a variable cytoplasmic loop， a fourth conserved transmembrane domain， and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel， displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by， and highly sensitive to， alpha-bungarotoxin. Once this receptor binds acetylcholine， it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. |
| Swiss Prot | P36544 |
| Gene ID | 1139 |
| Subcellular Location | Cytoplasm Cell membrane |
| Immunogen | Recombinant protein of human CHRNA7 |
| Public Immunogen Range | 164-290aa |
| Calculated MW | 11/56/59kDa |
| Observed MW | Bovine;Chicken |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Purity | CHRNA7 |
| Conjugation Concentration | bottle |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human Mouse Rat |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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