{{cart_num}}
My CartReactivity：Human,Mouse
Application：IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：51360
Purity：MBTPS2
Qty：
Size：
| Name | Anti-MBTPS2 Polyclonal Antibody |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | IHC 1:25-100. |
| Target | Rabbit |
| Background | Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6， ATF6B， SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11163209， PubMed:10805775).Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment， thereby releasing the N-terminal segment with a portion of the transmembrane segment attached (PubMed:10805775， PubMed:27380894， PubMed:9659902).Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775， PubMed:27380894， PubMed:9659902).Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209).Involved in intramembrane proteolysis during bone formation (PubMed:27380894).In astrocytes and osteoblasts， upon DNA damage and ER stress， mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1， leading to the inhibition of cell-cycle progression (PubMed:16417584). |
| Swiss Prot | O43462 |
| Gene ID | 51360 |
| Subcellular Location | Cytoplasm |
| Immunogen | Recombinant protein of human MBTPS2 |
| Public Immunogen Range | 96-186aa |
| Calculated MW | 57KDa |
| Observed MW | Bovine |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Purity | MBTPS2 |
| Conjugation Concentration | bottle |
| Conjugation | 34KDa |
| Specification | 50ul 100ul |
| Reactivity | Human Mouse |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no experimental images.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
