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My CartReactivity：Mouse,Rat,Human
Application：ELISA,WB,FCM,IHC
Clone Type：Monoclonal Antibody
Storage：Store at -20℃.Avoid freeze/thaw cycles.
Gene ID：468
Purity：ATF4
Qty：
Size：
| Name | Anti-ATF4 Monoclonal Antibody |
| Clone Type | Monoclonal Antibody |
| Subtype | IgG1 |
| Dilution Ratio | WB 1:1000-4000.IHC 1:50-500 FCM 10^6 cells+0.40 ug. |
| Target | Mouse |
| Background | Activating transcription factor 4 (ATF4) also known as cAMP-response element-binding protein 2 (CREB2) is a substrate of RSK2 and a basic leucine-zipper transcription factor (PMIDs: 16000305 17485283).ATF4 its a transcription factor that controls the transcriptional activity of mature osteoblasts.ATF4 is particularly critical for their timely onset and terminal differentiation as well as expression of Bsp and osteocalcin.Knockout animals displayed reduction or delay in bone mineralization and have severely reduced bone volume.ATF4 is also part of the PERK-eIF2α-ATF4-CHOP apoptosis pathway which is activated by ER stress and it likely plays a role related to tumor cell survival (PMIDs: 18083928 16000305 30134550). |
| Swiss Prot | P18848 |
| Gene ID | 468 |
| Subcellular Location | Cytoplasm cytoskeleton microtubule organizing center centrosome Cell membrane Nucleus |
| Immunogen | Recombinant protein of human ATF4 |
| Public Immunogen Range | 1-351aa |
| Calculated MW | 39kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. |
| Storage | Store at -20℃.Avoid freeze/thaw cycles. |
| Purity | ATF4 |
| Conjugation Concentration | bottle |
| Conjugation | 45-50kDa |
| Specification | 50ul 100ul |
| Reactivity | Human Mouse Rat |
| Application | WB IHC FCM ELISA |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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