Description:

Inhibition of bacterial protein synthesis by biochemical studies.

Antibacterial spectrum: Gram-negative and positive bacteria.

Use and synthesis method:

This product is for scientific research only and shall not be used for other purposes. Reference Use This product is a broad spectrum bacteriostatic agent, high concentration has bactericidal effect. In addition to common gram-positive bacteria, gram-negative bacteria and anaerobic bacteria, most Rickettsiella, Mycoplasma, Chlamydia, atypical Mycobacterium, spirochaeta are sensitive to this product. The action of this product against gram-positive bacteria is better than gram-negative bacteria, but enterococcus is resistant to it. Others such as actinomyces, anthrax, Listeria monocytogenes, Clostridium, nocardia are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant gonorrhoeae are also resistant to tetracycline. This product has good antibacterial action against Vibrio, Brucella, Campylobacter, Yersinia and other gram-negative bacteria, and has no antibacterial activity against Pseudomonas aeruginosa. This product has a certain antibacterial effect on some anaerobic bacteria, but it is far less than metronidazole, clindamycin and chloramphenicol, so it is not used clinically. Due to the extensive application of tetracycline over the years, the common clinical pathogens including gram-positive bacteria such as staphylococcus and gram-negative bacteria such as Enterobacter have serious resistance to tetracycline. In addition, there is cross-resistance between the same species. The mechanism of action of this product is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome and prevent the binding of aminoacyl-trNA at this position, thus inhibiting the growth of peptide linkage and affecting the synthesis of bacterial proteins.

Feature:

< p >(%) of heavy metals: 0.005 or less moisture content (%) : 2.0 pH (1%, water) 25 ℃ or less, than rotation: 1.8-2.8-255-240< / p >

Solubility:

Dissolve in water (10mg/ml), filter and remove bacteria, store at -20℃ for 1 month. The sterilized medium should be cooled to about 55℃ before adding tetracycline, and the reference working concentration is 12.5-15.0ug/ml. Plate medium containing tetracycline can be stored at 4℃ for 2 weeks.

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