CAS:2353-33-5
Appearance:White Powder
Storage:Store at 2-8℃,2 years
Purity:≥99.5%
Product introduction
5-aza-2 '-deoxycytidine, also known as decitabine or 5-aza-2' -deoxycytidine, is a natural 2' -deoxycytidine adenosine analogue. It inhibits the proliferation of tumor cells and prevents the occurrence of drug resistance by inhibiting DNA methyltransferase and reducing DNA methylation. It is the strongest DNA methylation-specific inhibitor known, belongs to S phase cell cycle specific drugs, and is suitable for the treatment of myelodysplastic syndrome (MDS). Hypomethylating agents can activate tumor suppressor genes and enhance the expression of regulatory genes such as differentiation genes in tumor cells, so they can achieve the purpose of treating MDS. After being phosphorylated, 5-aza-2 '-deoxycytidine (decitabine) exerts its antitumor effect. It acts directly on DNA and inhibits DNA methyltransferase, thereby hypomethylation of DNA and cell differentiation and death. Decitabine inhibits DNA methylation without affecting DNA synthesis in vitro. It can lead to demethylation of tumor cells and restore the normal function of genes, which is important for the control of cell differentiation and proliferation.
Precautions
This product is only used for research and experimental research.
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