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My CartCAS：39262-14-1
Purity：HPLC≥98%
Molecular Formula：C36H62O8
Molecular Weight：622.87
Appearance：White to off-white powder
Storage：Store at 2-8℃，2 years.
Qty：
Size：
| CAS | 39262-14-1 |
| Name | Compound K |
| Purity | HPLC≥98% |
| Molecular Formula | C36H62O8 |
| Molecular Weight | 622.87 |
| Appearance | White to off-white powder |
| Solubility | ≥10mg/mL in DMSO |
| Storage | Store at 2-8℃，2 years. |
| MDL | MFCD07772261 |
| SMILES | C[C@@]([C@@]12C)(CC[C@@]3([H])C4(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO)([H])CC2)([H])[C@]3(CC[C@@H]4O)C |
| InChI | InChI=1S/C36H62O8/c1-20(2)10-9-14-36(8，44-31-30(42)29(41)28(40)23(19-37)43-31)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(39)32(3，4)24(33)12-17-34(25，35)6/h10，21-31，37-42H，9，11-19H2，1-8H3/t21-，22+，23+，24-，25+，26-，27-，28+，29-，30+，31-，33-，34+，35+，36-/m0/s1 |
| Note | The reserve liquid is recommended to be packaged and frozen to avoid repeated freezing and thawing (-20℃, 1 month); The diluted working liquid is recommended to be used and prepared immediately |
| Unit | Bottle |
| Specification | 20mg |
Examples of using this product（for reference only）
HPLC
The analysis of CK was carried out using an Acchrom S6000 HPLC system equipped with Acchrom Unitary C18 HPLC column (4.6 × 250 mm, 5 μm). An aliquot of 40 μL standard CK at different concentrations (1–100 μM) and samples were injected into the column and detected by Ultraviolet (λ = 203 nm), and peak area was used to generate the calibration curve for quantification of CK in samples. The mobile phase was methanol–acetonitrile-water (45:45:10,v/v/v), and the flow rate was 1.0 mL/min.
References：
Liu D, Jiao S, Wei J, Zhang X, Pei Y, Pei Z, Li J, Du Y. Investigation of absorption, metabolism and toxicity of ginsenosides compound K based on human organ chips. Int J Pharm. 2020 Sep 25;587:119669. doi: 10.1016/j.ijpharm.2020.119669. Epub 2020 Jul 20. PMID: 32702454.
LC-MS/MS
The standard curve of CK and absorption samples were detected by LC-MS/MS system equipped with C18 HPLC column (4.6 × 250 mm, 5 μm) and analyzed by Xcalibur 2.2 SP1 application. An aliquot of 20 μL standard CK at different concentrations (0.05–50 μM) and samples were injected into the column and detected by MS for quantification. The mobile phase was methanol–acetonitrilewater (45:45:10, v/v/v), and the flow rate was 200 μL/min. MS detection was set in the range of 28–45 min.
References：
Liu D, Jiao S, Wei J, Zhang X, Pei Y, Pei Z, Li J, Du Y. Investigation of absorption, metabolism and toxicity of ginsenosides compound K based on human organ chips. Int J Pharm. 2020 Sep 25;587:119669. doi: 10.1016/j.ijpharm.2020.119669. Epub 2020 Jul 20. PMID: 32702454.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Investigation of absorption; metabolism and toxicity of ginsenosides compound K based on human organ chips
Click to check >>Author：Liu D; Jiao S; Wei J; Zhang X; Pei Y; Pei Z; Li J;
IF：4.8450
Publish_to：Int J Pharm
PMID：32702454
Compound K producing from the enzymatic conversion of gypenoside by naringinase
Click to check >>Author：Zheng Y; Zheng Z; Ming Y; Bai Y; Chen L; Huang W; Lin M; Liu S; Xiao J; Lin H.
IF：4.3000
Publish_to：Food Chem Toxicol
PMID：31103740
