| CAS |
29908-03-0 |
| Chinese Name |
S-腺苷-L-蛋氨酸 |
| English Name |
Ademetionine |
| Synonyms |
SAM;S-Adenosyl-L-methionine;AdoMet |
| Molecular Formula |
C15H22N6O5S |
| Molecular Weight |
398.44 |
| Solubility |
Soluble in Water ≥100mg/mL |
| Purity |
≥98% |
| Appearance |
White to yellow Solid |
| Storage |
Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 249-946-8 |
| MDL |
MFCD00871208 |
| SMILES |
O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3C[S+](CC[C@H](N)C([O-])=O)C |
| InChIKey |
MEFKEPWMEQBLKI-AIRLBKTGSA-N |
| InChI |
InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27/m0/s1 |
| PubChem CID |
34755 |
| Target Point |
Others |
| Passage |
Others |
| Background |
It is an intermediate metabolite of methionine, a methyl donor for over 100 different methyltransferase catalyzed reactions in the body, and a precursor molecule for the conversion of sulfur into GSH and the conversion of aminopropyl into polyamines. |
| Biological Activity |
Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.[1] |
| In Vitro |
Ademetionine(S-adenosylmethionine; SAMe)is a ubiquitous metabolite present in all cells and biological fluids，and serves as a methyl donor in a multitude of different methylation reactions involving proteins，phospholipids，catecholamines and DNA[1]. |
| In Vivo |
SAMe is able to cross the intestinal wall and increase plasma levels. Studies in rats reveal that absorption of the drug is much better after intraduodenal administration compared to oral administration. The systemic bioavailability after oral SAMe administration appears to be low. SAMe dose-dependently(12.5，25，50，100 and 200 mg/kg sc.)decreases immobility time in the forced swimming test in mice and rats. Chronic treatment with SAMe is associated with an increase in density of b-receptors，and a decrease in the affinity of a1 adrenoceptors for phenylephrine in rat cerebral membranes[1]. |
| Data Literature Source |
[1] Bottiglieri T. Expert Opin Investig Drugs. 1997，6(4):417-26. |
| Unit |
Bottle |
| Specification |
50mg 10mM*1mL in Water 100mg |
English
中文
Manual Download
