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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AdenosineCAS：58-61-7
Molecular Formula：C10H13N5O4
Molecular Weight：267.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 58-61-7 |
| Name | Adenosine |
| Molecular Formula | C10H13N5O4 |
| Molecular Weight | 267.24 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-389-9 |
| MDL | MFCD00005752 |
| SMILES | NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=NC=N1 |
| InChIKey | OIRDTQYFTABQOQ-KQYNXXCUSA-N |
| InChI | InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 |
| PubChem CID | 60961 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | Adenosine is an endogenous nucleoside distributed throughout human cells and is an important intermediate for the synthesis of adenosine triphosphate (ATP), adenine, adenylate, and adenosine arabinoside. It can directly enter the myocardium to be phosphorylated to generate adenylate. |
| Biological Activity | Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1-2]. |
| Data Literature Source | [1]. Fredholm BB. Adenosine，an endogenous distress signal，modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323. [2]. Borea PA，Gessi S，Merighi S，Vincenzi F，Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [3]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915. [4]. Zhou XT，et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
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