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Alantolactone

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Cat.No：IA0130 Solarbio

CAS：546-43-0

Molecular Formula：C₁₅H₂₀O₂

Molecular Weight：232.32

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	546-43-0
Name	Alantolactone
Molecular Formula	C₁₅H₂₀O₂
Molecular Weight	232.32
Solubility	Soluble in DMSO ≥10mg/mL
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 208-899-3
MDL	MFCD00046915
SMILES	O=C(O[C@@]1([H])[C@]2([H])C=C3[C@@H](C)CCC[C@]3(C)C1)C2=C
InChIKey	PXOYOCNNSUAQNS-AGNJHWRGSA-N
InChI	InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1
PubChem CID	72724
Target Point	STAT3
Passage	JAK/STAT Signaling
Background	Alantolactone is a selective inhibitor of STAT3 with antitumor activity.
Biological Activity	Alantolactone 是 STAT3 的选择性抑制剂，并具有抗肿瘤活性[1-2]。
Data Literature Source	[1]. Khan M，et al. Alantolactone induces apoptosis in HepG2 cells through GSH depletion，inhibition of STAT3 activation，and mitochondrial dysfunction. Biomed Res Int. 2013;2013:719858. [2]. Chun J，et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357(1):393-403
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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