| CAS |
1617-53-4 |
| Chinese Name |
穗花杉双黄酮 |
| English Name |
Amentoflavone |
| Synonyms |
穗花杉双黄酮;阿曼托黄酮;Amentoflavone;Didemethyl-ginkgetin; |
| Molecular Formula |
C30H18O10 |
| Molecular Weight |
538.46 |
| Solubility |
Soluble in DMSO ≥10mg/mL |
| Purity |
HPLC≥98% |
| Appearance |
Light yellow to yellow-green Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD00017470 |
| SMILES |
O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13 |
| InChIKey |
YUSWMAULDXZHPY-UHFFFAOYSA-N |
| InChI |
InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H |
| PubChem CID |
5281600 |
| Target Point |
Reactive oxygen species (ROS) |
| Passage |
Immunology & Inflammation |
| Background |
It is a biflavonoid compound with many biological activities, including anti-inflammatory, antioxidant, neuroprotective and other effects. |
| Biological Activity |
Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.[1-2] |
| In Vitro |
Amentoflavone induces morphological changes and reduces the percentage of viable MCF-7 cells. Amentoflavone induces apoptosis and chromatin condensation，DNA strand breaks in MCF-7 cells. Amentoflavone is also reported to induce cell-cycle arrest at the sub-G1 phase，and apoptosis via mitochondria-emanated intrinsic pathways in SiHa and CaSki human cervical cancer cells[1]. |
| In Vivo |
In an animal model，amentoflavone is found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice[1]. Amentoflavone can cross the blood-brain barrier. It effectively prevents pilocarpine-induced epilepsy in a mouse kindling model，suppresses NF-kB activation and expression，inhibits excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures，shortened attack time，and diminished loss and apoptosis of hippocampal neurons[2]. |
| Cell Experiment |
Approximately 2×105 MCF-7 cells/well in 24-well plates are treated with 250 μM amentoflavone，or with vehicle(DMSO，0.1% in culture media)-only and all cells are incubated for 6 to 72 h. For the examination of morphological changes，cells are photographed under a phase-contrast microscope.[1] |
| Animal Experiment |
Animal Models: Kunming mice;Dosages: 25 mg/kg;Administration: intragastrically administered[2] |
| Data Literature Source |
[1] Pei JS，et al. In Vivo. 2012，26(6):963-70.
[2] Zhang Z，et al. Neural Regen Res. 2015，10(7):1125-33. |
| Unit |
Bottle |
| Specification |
5mg 10mM*1mL in DMSO 10mg |
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