| CAS |
39831-55-5 |
| Chinese Name |
硫酸阿米卡星 |
| English Name |
Amikacin Sulfate |
| Synonyms |
BAY-416651 sulfate;BB-K8;Pierami;阿米卡星硫酸盐 |
| Molecular Formula |
C22H43N5O13·2H2SO4 |
| Molecular Weight |
781.76 |
| Solubility |
Soluble in Water ≥10mg/mL |
| Enzyme Activity/Titer |
674-786μg/mg |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 254-648-6 |
| MDL |
MFCD00167475 |
| SMILES |
OS(O)(=O)=O.OS(O)(=O)=O.O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO |
| InChIKey |
FXKSEJFHKVNEFI-GCZBSULCSA-N |
| InChI |
InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1 |
| PubChem CID |
38351 |
| Target Point |
Bacterial |
| Passage |
Anti-infection |
| Background |
It is an aminoglycoside antibiotic. It has bactericidal effect, acts on the 30S subunit of bacterial ribosome, inhibits bacterial protein synthesis, and has a good effect on most Enterobacteriaceae bacteria. |
| Biological Activity |
Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1-2]. |
| In Vitro |
Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides，Mycobacterium avium-intracellulare，and certain species of rapid-growing mycobacteria(that is，M. chelonae and M. fortuitumi)[1].Amikacin(100-1500 μM)causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM[3]. |
| In Vivo |
Amikacin(320mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats)treatment increases the chance of serious hearing loss in rats in vivo[3]. |
| Animal Experiment |
Animal Model: Male Fischer 344 rats(40-50-day-old);Dosage: 320 mg/kg;Administration: Subcutaneous injection; daily; for 10 days[3] |
| Data Literature Source |
[1]. Edson，R.S. and C.L. Terrell，The aminoglycosides. Mayo Clin Proc，1999. 74(5): p. 519-28.
[2]. Ristuccia AM，et al. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25.
[3]. Sian R Kitcher，et al. ORC-13661 Protects Sensory Hair Cells From Aminoglycoside and Cisplatin Ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764. |
| Unit |
Bottle |
| Specification |
100mg 10mM*1mL in Water 500mg |
English
中文
Manual Download
