CAS |
549-18-8 |
Chinese Name |
盐酸阿米替林 |
English Name |
Amitriptyline Hydrochloride |
Synonym |
Annoyltin;Tryptizol;Domical |
Unit |
Bottle |
Purity |
HPLC≥98% |
Molecular Formula |
C20H23N·HCl |
Molecular Weight |
313.87 |
Appearance |
White to yellow solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in water/DMSO |
MDL |
MFCD00012537 |
EC |
EINECS 208-964-6 |
InChIKey |
KFYRPLNVJVHZGT-UHFFFAOYSA-N |
InChI |
InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H |
PubChem CID |
11065 |
SMILES |
CN(C)CC/C=C1C2=CC=CC=C2CCC3=C\1C=CC=C3.Cl |
Description |
It is a SERT and NET inhibitor. It also binds to DAT and also inhibits Adrenergic receptor, mAChR, Histamine receptor and 5-HT receptor. In addition, it is a TrkA and TrkA receptor agonist with strong neurotrophic activity. |
Target Point |
SERT;NET;DAT;Adrenergic receptor;mAChR;Histamine receptor;5-HT receptor;TrkA |
Passage |
Neuronal Signaling;Membrane Transporter&Ion Channel;Endocrinology & Hormones;GPCR & G Protein;Immunology & Inflammation |
Data Literature Source |
[1] Vaishnavi SN, et al. Biol Psychiatry, 2004, 55(3), 320-322.
[2] Nguyen T, et al. Mol Pharmacol, 2001, 59(3), 427-433.
[3] Rauser L, et al. J Pharmacol Exp Ther, 2001, 299(1), 83-89.
[4] Werling LL, et al. Exp Neurol, 2007, 207(2), 248-257.
[5] Onali P, et al. J Pharmacol Exp Ther, 2010, 332(1), 255-265.
[6] Jang SW, et al. Chem Biol, 2009, 16(6), 644-656.
[7] Ushijima K, et al. J Pharmacol Exp Ther, 2005, 315(2), 764-770.
[8] Troelsen KB, et al. Psychopharmacology (Berl), 2005, 1 |
Specification |
50mg 10mM*1mL (in DMSO) 500mg |