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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > AmLodipine BesylateCAS：111470-99-6
Molecular Formula：C20H25ClN2O5·C6H6O3S
Molecular Weight：567.05
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 111470-99-6 |
| Name | AmLodipine Besylate |
| Molecular Formula | C20H25ClN2O5·C6H6O3S |
| Molecular Weight | 567.05 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1312995-182-4 |
| MDL | MFCD00887594 |
| SMILES | O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC.O=S(C3=CC=CC=C3)(O)=O |
| InChIKey | ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9) |
| PubChem CID | 60496 |
| Target Point | Calcium Channel |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | It is a long-acting calcium channel inhibitor. |
| Biological Activity | Amlodipine, a dihydropyridine Ca2 + channel blocker, is reported to inhibit proliferation of human epidermoid carcinoma A431 cells, and specifically attenuates Ca2 + responses evoked by thapsigargin, an inhibitor of endoplasmic reticulum Ca2 +-ATPases.A potential antitumor action for amlodipine in vitro and in vivo, which may be in part mediated by inhibiting Ca2 + influx evoked by the passive depletion of internal Ca2 + stores and by PLC-linked agonist stimulation.[1]. |
| Data Literature Source | [1]. Yoshida J，et，al. Antitumor effects of amlodipine，a Ca2+ channel blocker，on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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