CAS |
22839-47-0 |
Chinese Name |
阿斯巴甜 |
English Name |
Aspartame |
Synonyms |
阿斯巴甜;阿司帕坦;糖肽;L-天冬氨酰-L-苯丙氨酸甲酯;蛋白糖;甜乐; |
Molecular Formula |
C14H18N2O5 |
Molecular Weight |
294.3 |
Solubility |
Soluble in Water/DMSO |
Purity |
HPLC≥99% |
Appearance |
White to off-white Solid |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC |
EINECS 245-261-3 |
MDL |
MFCD00002724 |
SMILES |
O=C(OC)[C@@H](NC([C@@H](N)CC(O)=O)=O)CC1=CC=CC=C1 |
InChIKey |
IAOZJIPTCAWIRG-QWRGUYRKSA-N |
InChI |
InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1 |
PubChem CID |
134601 |
Target Point |
Others |
Passage |
Others |
Background |
Aspartame is a non-sugar sweetener. |
Biological Activity |
Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1-2]. |
In Vitro |
Aspartame is composed of phenylalanine(an important role in neurotransmitter regulation),aspartic acid(an excitatory neurotransmitter in the central nervous system)and methanol[2]. |
In Vivo |
Aspartame(4000 mg/kg bw/day; p.o.)shows no adverse effect in acute,subacute and chronic toxicity studies with aspartame,and its decomposition products,conducted in mice,rats,hamsters and dogs[1]. |
Data Literature Source |
[1]. Magnuson BA,et,al. Aspartame: a safety evaluation based on current use levels,regulations,and toxicological and epidemiological studies. Crit Rev Toxicol. 2007;37(8):629-727. [2]. Humphries P,et,al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62. |
Unit |
Bottle |
Specification |
100mg 10mM*1mL in DMSO 500mg |