CAS |
5908-99-6 |
Chinese Name |
硫酸阿托品一水 |
English Name |
Atropine Sulfate Monohydrate |
Synonyms |
一水合硫酸阿托品;Atropine sulfate hydrate;硫酸阿托品;Tropine tropate sulfate monohydrate;DL-Hyoscyamine sulfate monohydrate |
Molecular Formula |
2(C17H23NO3)·H2O·H2SO4 |
Molecular Weight |
694.83 |
Solubility |
Soluble in Water/DMSO ≥10mg/mL |
Purity |
HPLC≥98% |
Appearance |
White to off-white Solid |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC |
EINECS 200-235-0 |
MDL |
MFCD00074815 |
SMILES |
OS(O)(=O)=O.O=C(C(C1=CC=CC=C1)CO)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2.[0.5] |
InChIKey |
JPKKQJKQTPNWTR-BRYCGAMXSA-N |
InChI |
InChI=1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15?,16?;; |
PubChem CID |
656678 |
Target Point |
mAChR |
Passage |
Neuronal Signaling |
Background |
Atropine Sulfate Monohydrate is a broad-spectrum, competitive muscarinic acetylcholine receptor (mAChR) antagonist. |
Biological Activity |
Atropine sulfate monohydrate是一种竞争性毒蕈碱型乙酰胆碱受体拮抗剂,IC50为2.5 nM。[1] |
In Vitro |
Atropine增加神经递质多巴胺的释放到体外(100-500 mM)和体内玻璃体(250 mg)。Atropine诱导体外大脑皮层的扩散性抑制(SD)。Atropine减少ERG b和d-波,导致RPE电势的衰减振荡,并逆转了ERG c波。在视网膜中,Atropine仅在产生严重非特异性副作用的剂量抑制近视。[1] |
In Vivo |
Atropine(1.0 毫克/千克,腹腔注射),但不是methylatropine(1.0 毫克/千克,腹腔注射),在训练小鼠后立即给予可以防止两种剂量的抗胆碱酯酶的诱导的记忆力的增强。[2] 在犬中,Atropine有效防止心动过缓和第二度心脏传导阻滞,而导致交替脉和高血压。[3] 在大鼠中,Atropine在10 nM neostigmine存在时对处理诱导的乙酰胆碱输出没有影响,但在100 nM和1000 nM neostigmine存在时会导致更大和更长的增加。[4] |
Data Literature Source |
[1] Schwahn HN,et al. Vis Neurosci,2000,17(2),165-176. [2] Boccia MM,et al. Neurosci Lett,2003,345(2),97-100. [3] Ko JC,et al. J Am Vet Med Assoc,2001,218(1),52-58. [4] Moor E,et al. Neuroscience,1998,82(3),819-825. |
Unit |
Bottle |
Specification |
20mg 10mM*1mL in DMSO 10mM*1mL in Water 50mg 100mg |