| CAS |
10309-37-2 |
| Chinese Name |
补骨脂酚 |
| English Name |
Bakuchiol |
| Synonyms |
补骨脂酚;(Rac)-EM-652;pantosin; |
| Molecular Formula |
C18H24O |
| Molecular Weight |
256.38 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
Colorless to yellow Liquid |
| Storage |
Store at 2-8℃，2 years |
| Density |
0.96g/mL |
| EC |
EINECS 685-515-4 |
| MDL |
MFCD01707441 |
| SMILES |
OC1=CC=C(/C=C/[C@](C)(C=C)CC/C=C(C)\C)C=C1 |
| InChIKey |
LFYJSSARVMHQJB-QIXNEVBVSA-N |
| InChI |
InChI=1S/C18H24O/c1-5-18(4,13-6-7-15(2)3)14-12-16-8-10-17(19)11-9-16/h5,7-12,14,19H,1,6,13H2,2-4H3/b14-12+/t18-/m1/s1 |
| PubChem CID |
5468522 |
| Target Point |
p38 MAPK;Blk;Hck |
| Passage |
Others |
| Background |
Bakuchiol has anti-inflammatory and antibacterial activity. |
| Biological Activity |
Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.[1-2] |
| In Vitro |
Bakuchiol inhibits EGF-induced signaling pathways downstream of Hck，Blk and p38 MAPK，including the MEK/ERKs，p38 MAPK/MSK1 and AKT/p70S6K pathways. Bakuchiol decreases viability and inhibits anchorage-independent growth of A431 human epithelial carcinoma cells. It also inhibits the proliferation of A549 human lung adenocarcinoma cells，SK-MEL-2 human melanoma cells and B16 mouse melanoma cells by inducing apoptosis[1]. |
| In Vivo |
Bakuchiol reduces A431 xenograft tumor growth in an in vivo mouse model[1]. Bakuchiol treatment attenuates acute lung injury following sepsis by suppressing inflammation，oxidative stress，and endothelial barrier disruption[2]. |
| Cell Experiment |
Cells(1.5 × 106)are cultured in 100-mm dishes for 48 h，and then serum starved in 0.1% FBS-MEM for 24 h. The cells are then treated with bakuchiol(0，5，10，and 20 μM)for 1 h before exposure to 10 ng/ml EGF for an additional 30 min. Cells are harvested and disrupted with lysis buffer before protein concentration is measured using a dye-binding protein assay kit.[1] |
| Animal Experiment |
Animal Models: 6-week-old，BALB/c-nu mice;Dosages: 10 or 40 mg/kg;Administration: i.p.[1] |
| Data Literature Source |
[1] Kim JE，et al. Oncotarget. 2016，7(12):14616-27.
[2] Zhang X，et al. Inflammation. 2017，40(2):351-359. |
| Unit |
Bottle |
| Specification |
20mg |
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