Brefeldin A_Autophagy_Autophagy_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

Biochemical Reagents

Antibiotics (Biochemical Reagents) Vitamins Carbohydrates and Derivatives Animal & Plant Hormones Surfactants Amino Acids & Peptides & Protein Enzymes & Coenzymes & Inhibitors Bases & Nucleic Acids & Derivatives Acids & Salts & Amines Biochemical Reagents Building Blocks PEG Derivatives Universal Buffer

Protein and Immunity

Protein Extraction/Quantification Protein Electrophoresis Other Reagents Immunotechnical Services Recombinant Protein Whole Cell Protein

Small Molecule Compounds

Star Products Inhibitors & Antagonists & Agonists Peptides PROTAC Anti-Infection Plant Hormones Amino Acids & Derivatives Vitamins & Derivatives Carbohydrates & It's Analogues Cosolvent & Solubilizer Dye & Probe Reaction Substrate & Physicochemical Detection

Antibodies

Primary Antibodies Secondary Antibodies Loading Control Antibodies Label Antibodies Antigens Plant Antibodies Viral Antibodies Bacterial Antibodies Small Molecule Antibodies RNA Antibodies

ELISA

Human Rats Mice Other Species Antibody Pairs Self-Prepare Reagents

Biochemical Assay Kits

Micromethod Macromethod HPLC Anti-Reverse Series Oxidation Series Antioxidant Series Coenzyme Ⅰ Series Coenzyme Ⅱ Series Glycolysis Series Glutathione Series Vitamin C Metabolism Series ATP Series Nitrogen Metabolism Series Amino Acid Metabolism series Esterase Series Mitochondrial Respiratory Chain Series Tricarboxylic Acid Cycle Series Protease Series Fatty Acid Metabolism Series Starch Series Sucrose Series Sugar Metabolism Series Ion Series Soil Series Signal Series Transhydrogenase Series Other Series Protein quantification Pectin Series Photosynthesis Series Gluconeogenesis Series Vitamin Series

Standard References

Star Products Control Herbs Standard Solution CP Standards Imported Standards Standard References Derivatization Reagent Ion Pair Reagents Domestic Standard Material UV Spectroscopy Standards

Dye Reagents

Stain Solution Fixation Solution Dye

Cell Biology

Cell Detection Reagents Cell Growth Factor Cell Line Cell Culture Cell Isolation & Digestion Cell Staining & Probe Cell Transfection Limulus Lysate

Molecular Biology

Nucleic Acid Extraction/Purification PCR Nucleic Acid Electrophoresis Recombinant Clone Expression Molecular Hybridization

Chromatography Media

Fillers Prepacked Column

Microbial Culture

Strains Drug Sensi-Disc Culture Medium Others

Instruments & Consumables

Consumables Imported Consumables Pipette Instruments Consignment Products

Magnetic Beads

Purified Magnetic Beads Immunoprecipitation Base Magnetic Beads

Nanomaterials

Graphite/Graphene Carbon Nanomaterials Molecular Sieve Other Nanomaterials Inorganic Nanomaterials Metallic Nanomaterial Graphenoid

Peptides

Substance P & Related Peptides Pituitary Adenylate Cyclase Activating Peptides Bag Cell Peptides Cholecystokinin RGD/RAD Peptides Opioid Peptides Cancer Research Apelin/APLN Viral-Associated Peptides Laminin Peptides Pituitary & Hypothalamic Hormone Melanocyte-Stimulating Hormone/MSH Adrenocorticotropic Hormone/ACTH Growth-Promoting Hormone Neuropeptides Thymopoietin & Thymosin Peptides Endothelin & It's Analogues Protein Kinases & Related Peptides Amyloid Peptides Multiple Sclerosis Peptide Tag Osteoporosis Research Matrix Metalloproteinase Substrate Hormones Calcitonin Antimicrobial Peptides Antioxidant Peptides Insect Neuropeptides Casein Morphine Peptides Enzyme Substrate Peptides Prolactin-Releasing Peptides Enkephalin Brain Natriuretic Peptides Endorphin & Endorphin Thrombin-Related Peptides Others Dynorphin Neurokinin Neuropeptides & Related Peptides Renal Myelin Peptides Growth Hormone & Growth Factor Somatostatin & It's Analogues Leptin Fragment Peptides Bombesin Gastrin Cell-Penetrating Peptides Fibronectin & Extracellular Matrix Peptides Anti-Inflammatory Peptides Natriuretic Peptides A Angiotensinogen Substrates & Inhibitors Angiopoietin & Angiotensin Bradykinin Thrombospondin Hematology Inflammation Research Allatostatins Inhibitor-Related Peptides Cosmetic Peptides

Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
IB0270-1ml	Inquiry	Inquiry	Inquiry	Inquiry
IB0270-5mg	Inquiry	Inquiry	Inquiry	Inquiry
IB0270-10mg	Inquiry	Inquiry	Inquiry	Inquiry

CAS	20350-15-6
Chinese Name	布雷非德菌素 A
English Name	Brefeldin A
Synonym	布雷非德菌素A;蛋白转运抑制剂;Ascotoxin;BFA;棉萎丹;棉萎灵;
Unit	Bottle
Purity	≥98%
Molecular Formula	C₁₆H₂₄O₄
Molecular Weight	280.36
Appearance	White to off-white solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
MDL	MFCD00083258
EC	EINECS 606-528-3
InChIKey	KQNZDYYTLMIZCT-KQPMLPITSA-N
InChI	InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
PubChem CID	5287620
SMILES	O[C@@H]1C[C@]2([H])[C@@](/C=C/CCC[C@H](C)OC(/C=C/[C@H]2O)=O)([H])C1
Description	Brefeldin A is a lactone antibiotic and a specific inhibitor of protein transport. It is also an autophagy and mitophagy inhibitor. It is also a CRISPR/Cas9 agonist, which can inhibit HSV-1 virus and has anticancer activity.
Target Point	Autophagy; CRISPR/Cas9; Mitophagy; HSV; Antibiotic
Passage	Autophagy;Apoptosis; Anti-infection
Data Literature Source	[1]. Alvarez C, et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78(1):1-14. [2]. Colanzi A, et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9. [3]. Tseng CN, et al. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014 Oct 29;19(11):17464-77. [4]. Wang J, et al. Erythroleukemia cells acquire an alternative mitophagy capability. Sci Rep. 2016 Apr 19;6:24641. [5]. Yu C, et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell. 2015 Feb 5;16(2):142-7.
Specification	5mg 10mg 10mM*1mL (in DMSO)