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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > BufalinCAS：465-21-4
Molecular Formula：C24H34O4
Molecular Weight：386.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 465-21-4 |
| Name | Bufalin |
| Molecular Formula | C24H34O4 |
| Molecular Weight | 386.53 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00056525 |
| SMILES | O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O)C1)C)([H])[C@]2([H])CC3)(CC[C@@H]4C(C=C5)=COC5=O)[C@]34C |
| InChIKey | QEEBRPGZBVVINN-BMPKRDENSA-N |
| InChI | InChI=1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1 |
| PubChem CID | 9547215 |
| Target Point | Na+/K+ ATPase |
| Passage | Membrane Transporter&Ion Channel |
| Background | Bufalin, an immunoactive component of toad venom, is a potent Na+/K+-ATPase inhibitor that binds to the subunits α1, α2 and α3 of Na+/K+-ATPase, α1, α2 and α3. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Bufalin reduces myocardial infarction-induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL-1β signalling pathway
Click to check >>Author：Xiang Wei; Yang Lv; Chenxi Yang; Rifeng Gao; Su Zo
IF：2.9630
Publish_to：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
PMID：37243403
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