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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > CapsaicinCAS：404-86-4
Molecular Formula：C18H27NO3
Molecular Weight：305.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 404-86-4 |
| Name | Capsaicin |
| Molecular Formula | C18H27NO3 |
| Molecular Weight | 305.42 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-969-8 |
| MDL | MFCD00017259 |
| SMILES | CC(C)/C=C/CCCCC(NCC1=CC=C(O)C(OC)=C1)=O |
| InChIKey | YKPUWZUDDOIDPM-SOFGYWHQSA-N |
| InChI | InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+ |
| PubChem CID | 1548943 |
| Target Point | TRP Channel |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Capsaicin is a TRPV1 agonist. |
| Biological Activity | Capsaicin是一种 TRPV1 激动剂，在HEK293细胞中的 EC50 为0.29 μM。[1-6] |
| IC50 | EC50: 290nM(hTRPV1，in HEK293 cell)[1] |
| Data Literature Source | [1]. McNamara FN，et al. Effects of piperine，the pungent component of black pepper，at the human vanilloid receptor (TRPV1). Br J Pharmacol. 2005 Mar;144(6):781-90. [2]. Shin YH，et al. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules. 2016 Jun 25;21(7). [3]. Le TD，et al. Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells. Yonsei Med J. 2012 Jul 1;53(4):834-41. [4]. Anandakumar P，et al. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Jun 6;17(2):254-259. [5]. Kagawa Y，et al. Investigation of capsaicin-induced superficial punctate keratopathy model due to reduced tear secretion in rats. Curr Eye Res. 2013 Jul;38(7):729-35. [6]. Wang J，et al. Anti-inflammatory and retinal protective effects of capsaicin on ischaemia-induced injuries through the release of endogenous somatostatin. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):803-814. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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