CAS |
76822-21-4 |
Chinese Name |
丹参素 |
English Name |
Danshensu |
Synonyms |
Salvianic acid A;Dan shen suan A |
Molecular Formula |
C9H10O5 |
Molecular Weight |
198.17 |
Solubility |
Soluble in Water ≥2mg/mL;Soluble in Ethanol/DMSO ≥10mg/mL |
Purity |
HPLC≥98% |
Appearance |
White to off-white Solid |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL |
MFCD09038703 |
SMILES |
OC1=C(O)C=CC(C[C@@H](O)C(O)=O)=C1 |
InChIKey |
PAFLSMZLRSPALU-MRVPVSSYSA-N |
InChI |
InChI=1S/C9H10O5/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8,10-12H,4H2,(H,13,14)/t8-/m1/s1 |
PubChem CID |
11600642 |
Target Point |
Nrf2;Cytochrome P450 |
Passage |
NF-κB;Metabolic Enzyme&Protease |
Background |
Danshensu is an orally active phenolic compound that activates the Nrf2 signaling pathway and has protective cardiovascular activity. |
Biological Activity |
Danshensu 是丹参的有效成分,能够激活 Nrf2 信号通路,保护心血管。Danshensu 可抑制 CYP2E1 和 CYP2C9,对应的IC50值分别为36.63 μm和 75.76 μm。[1-3] |
In Vitro |
丹参素(DSS)显著降低冠状动脉流出物和心肌梗塞大小的标记酶(肌酸激酶和乳酸脱氢酶)的水平。这可能显著促进I/R损伤后心脏功能的恢复。 DSS还具有ROS清除活性,并通过激活由Akt和ERK1介导的核因子红细胞-2相关因子2(Nrf2)信号通路,促进内源性抗氧化剂如SOD,CAT,MDA,GSH-PX和HO-1活性。 2在蛋白质印迹分析[2]。 |
In Vivo |
在正常tHcy的大鼠中用单剂量丹参素进行急性治疗不会改变血浆tHcy。相比之下,丹参素显著降低了tHcy升高的大鼠的tHcy。用丹参素处理后相对较高的半胱氨酸和谷胱甘肽水平表明其降低tHcy的作用是通过增加反式硫化途径的活性[1]。 |
Data Literature Source |
[1]. YG Cao,et al. Beneficial effects of danshensu,an active component of Salvia miltiorrhiza,on homocysteine metabolism via the trans-sulphuration pathway in rats. Br J Pharmacol. 2009 Jun; 157(3): 482–490. [2]. Yu J,et al. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling. Int J Clin Exp Med. 2015 Sep 15;8(9):14793-804. |
Unit |
Bottle |
Specification |
10mg 10mM*1mL in Water 50mg |